Is this opioid analgesic tolerance?
نویسندگان
چکیده
منابع مشابه
Non-opioid analgesic poisoning.
Since the first cases of severe and fatal liver damage were reported in 1966,1,2 overdose of paracetamol has become the cause of 100–200 deaths in the UK each year.3 Paracetamol toxicity remains the leading cause of fulminant hepatic failure in the UK and is a common reason for liver transplantation.4,5 Knowledge of the toxic mechanism (Fig 1) has led to effective antidotes which provide substr...
متن کاملManagement of opioid analgesic overdose.
Copyright © 2012 Massachusetts Medical Society. Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient’s part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse.1,2 Three features are key to an understanding of opioid analgesic toxicity. First, opioid ana...
متن کاملOpioid tolerance or opioid withdrawal?
To the Editor: We thank Kim et al. for their recent work examining the effect of intraoperative remifentanil on postoperative analgesia in children.1 Certainly, the pharmacokinetic profile of this potent opioid is attractive in modern anesthetic practice, and a thorough understanding of the principles behind tolerance, hyperalgesia, and withdrawal of remifentanil are critical for its safe admin...
متن کاملThe delta-opioid receptor is sufficient, but not necessary, for spinal opioid-adrenergic analgesic synergy.
Spinal administration of opioid and α2-adrenergic receptor (α2AR) agonists produces analgesia, and agonists interact synergistically when coadministered. The molecular mechanism underlying this synergy is largely unknown. Pharmacological studies have identified both the delta and the mu-opioid receptors (DOR and MOR) as candidate receptors capable of interacting synergistically with α2AR agonis...
متن کاملDexmedetomidine as Part of a Multimodal Analgesic Treatment Regimen for Opioid Induced Hyperalgesia in a Patient with Significant Opioid Tolerance
Acute postoperative pain in patients with opioid tolerance creates a significant management challenge for anesthesiologists and pain medicine physicians. A multimodal approach is key; however other factors can complicate management such as opioid induced hyperalgesia. We present the case of a patient on large amounts of intrathecal opioids for chronic pain syndrome with opioid induced hyperalge...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 1995
ISSN: 0885-3924
DOI: 10.1016/0885-3924(95)00088-g